Disease
Onset

ICE
Change

Disease
Pathology

ICE Change is Central to Disease Development
What is ICE Change?
ICE change is a significant shift in the environment of a healthy cell to a state that is detrimental on the behavior, growth, or 'life processes' in the cell.  ICE change occurs due to disease onset or following injury and is regulated by ICE regulators.
What are ICE Regulators?
ICE regulators revert ICE change, bringing the cell back to a healthy ICE before disease/injury. ICE regulators are only activated when they detect significant ICE change, which occurs in a disease state or injury.

Therapeutically targeting ICE regulators allows us to slow, stop or revert disease/injury.  This novel approach can transform the treatment paradigm across a broad-spectrum of diseases.
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Since 2018, >4,000 Journal articles have been published on ICE and its essential role in disease pathogenesis and treatment

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