Developing Therapeutics Targeting ICE Regulators 

A heatmap of changes in cell behaviour following environmental change.

Image taken from Killaars et al., 2018, Adv.Sci.2019, 6, 1801483

MicroQuin focuses in-house efforts on Cancer, while progressing Anti-Virals and Neuro with the support of collaborators.

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Lead Program
- Oncology

All Cancers induce an extreme ICE, which hyperactivates ICE regulators to neutralize ICE change, and promote cancer survival. MicroQuin’s therapeutics selectively inhibit cancer ICE regulators to induce death.

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MicroQuin’s lead compound selectively binds cancerous cells in vivo to induce rapid tumor cell death (>95% in 28 day).  No toxicity or adverse effects were measured.

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Treatment of breast cancer tumor with placebo (untreated), standard of care (Tamoxifen), or MicroQuin's therapeutics (MQ treatment). 

 
Anti-Viral
support by NIAID

Viruses hijacks the host cell to establish an ICE that enables them to replicate and spread. MicroQuin’s therapeutics activate ICE regulators, neutralizing viral-induced ICE changes, resulting in full viral inhibition.

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MicroQuin’s anti-virals induce >99.9% viral inhibition from a single dose, thereby stopping viral replication and spread.

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Neuro

Neurodegenerative disease is a ‘catch all term’ for a complex process of ICE changes that result in neurological damage. In the case of TBI, all secondary injury is caused by ICE change, enabling injury progression.

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MQ Therapeutics can reverse secondary brain injury / ICE change, transforming damaged neurons into uninjured neurons

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